Nur fatmawati
16611047
Curcumi-piperine/curcumin-quercetin/curcumin-silibinin dual drug-loaded nanoparticulate combination therapy : A novel approach to target and treat multidrug-resistant cancers.
Multidrug resistance
(MDR) is the mechanism which many cancer develop resistance to chemotherapy
drug, resulting in minimal cell death and the expansion of drug-resistant
tumors. To address problem of resistance, researchers have developed nanoparticles that simultaneously deliver chemotherapy drugs to tumors and inhibit
the MDR proteins that pump the therapeutic drugs out of the cell. The process
is known as chemosensitization, as blocking this resistance renders the tumor
highly sensitive to the cancer-killing chemotherapy. Curcumin is a bright
yellow chemical produced by some plants. It is the principal curcuminoid of
turmeric, a member of the ginger family, Zingiberaceae. It is sold as an herbal
supplement, cosmetics ingredient, food flavoring, and food coloring.
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