Article "Human rhinovirus infection induces local and systemic immunological tolerance in healthy volunteers" (12th)

Clarisa livia
16611022


According to the study, most ICU patients suffer from respiratory viral infections. Human Rhinovirus (HRVs) is the most common cause of the common cold. The impact of recurrent HRV exposure and thus the possibility of viral immunoparalysis development has never been studied. Furthermore, although lethal HRV-C may cause severe systemic and severe infections in children and adults and less virulent HRV-A strains can cause severe infections in immunocompromised patients as well, the systemic inflammatory effects and HRV-A respiratory tract induced by HRV has not been studied in healthy subjects. Finally, it remains to be determined whether serostatus alters the HRV inflammatory response.

HRV infection does not produce an inflammatory response in seropositive subjects and does not have an effect on the lower respiratory tract. Furthermore, a second inoculation with HRV was one week after the first result in a reduced local and systemic inflammatory response. This may be an explanation for increased susceptibility to secondary infections following respiratory viral infection in ICU patients.