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Several epidemiological studies have reported that many comorbidities in migraine, most of which are identified through questionnaires based on self-reported diagnoses. Similarly, pharmacoepidemiological studies have also identified some comorbidities, they evaluated migraine comorbidity by using and comparing data obtained with different study methods, with the aim of minimizing yield variability.
Their study did not confirm that many comorbidities were reported to be associated with migraines, particularly those involved in cardiovascular risk. The evidence of contrast in the literature may be due to intrinsic bias in the study method: group, age not comparable, gender differences, marker drugs used from labels, and diagnostic uncertainty.
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