Article "Effect of eight days bed rest on the incretin effect in healthy volunteers" (11th)

Clarisa livia
16611022


When admitted to the hospital, and especially to the intensive care unit, dramatically decreased the level of physical activity, which converts glucose metabolism into a pre-diabetic state. Patients with critical illness often have spontaneous hyperglycemia, which is associated with increased morbidity and mortality. The incretin glucagon hormone is secreted from the intestine in response to glucose load and stimulates up to 70% insulin secretion from pancreatic beta cells in healthy individuals, named incretin effects. The incretin effect is reduced in critically ill patients, but the underlying mechanism has not been determined.

Blood glucose and serum insulin were higher during OGTT after rest and the Matsuda index decreased, indicating insulin resistance. The incretin effect is not affected. Thus, bed rest does not explain the reduced incretin effect in critically ill people.