Nur fatmawati
16611047
Matrix-Degrading metalloproteinasesin photoaging.
In
contrast to the results presented above, cell culture and skin equivalent model
studies have concluded that dermal fibroblasts are the major source of MMPs
that are expressed in response to UV irradiation. The reasons for the
discrepancies between responses of human skin cells in vivoand responses of cultured
skin cells in vitro are not
known. However, there are many other examples of cultured skin cells failing to
mimic the behavior of cells in vivo.
Obviously, it is important to compare, whenever possible, results obtained from
simple model systems with those obtained from direct in vivo observations Ultraviolet (UV) irradiation from the sun adversely
impacts skin health through complex, multiple molecular pathways.Damage to the
dermal connective tissue is a hallmark of photoaged skin. Disruption of the
normal architecture of skin connective tissue impairs skin function and causes
it to look aged. UV irradiation induces expression of certain members of the
matrix metalloproteinase (MMP) family, which degrade collagen and other
extracellular matrix (ECM).
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